Beilstein J. Org. Chem.2021,17, 1600–1628, doi:10.3762/bjoc.17.114
synthesis of a wide variety of relevant 1,4,5-trisubstituted 1,2,3-triazole molecules are reported. The synthesis of this category of diverse fullyfunctionalized1,2,3-triazoles has become a necessary and unique research subject in modern synthetic organic key transformations in academia, pharmacy, and
industry. The current review aims to cover a wide literature survey of numerous synthetic strategies. Recent reports (2017–2021) in the field of 1,4,5-trisubstituted 1,2,3-triazoles are emphasized in this current review.
Keywords: azides; Click reaction; [3 + 2]‐cycloaddition; fullyfunctionalized1,2,3
-triazoles; N-containing heterocycles; 1,4,5-trisubstituted 1,2,3-triazoles; Introduction
A high number of N-heterocycles [1][2][3][4] are identified, and this number is increasing very quickly [5][6][7][8]. Among them, the small heterocyclic ring of the 1,2,3-triazole is present in a broad variety of
PDF
Graphical Abstract
Figure 1:
Some significant triazole derivatives [8,23-27].